The Opportunity:

We are seeking a Senior Bioinformatician to join our Bioinformatics team and contribute to the development, validation, and operational deployment of analytical pipelines supporting our liquid-biopsy colorectal cancer (CRC) screening programs. This hands-on role will focus on implementing robust, high-quality bioinformatics solutions for NGS- and methylation-based assays in the context of clinical studies and regulated product development.

You will be part of a team that is passionate about developing novel diagnostic tests for the early detection of cancers. As part of the team, you will be in a Company that aims more than to become one of the leaders in the industry. We want to have a huge positive impact on society by achieving the ambitious purpose of “making cancer a curable disease by detecting it earlier”.

How you’ll contribute:

· Develop, optimize, and maintain bioinformatics pipelines for cfDNA methylation analysis and NGS-based assays (e.g., targeted methylation sequencing, WGBS, hybrid capture).

· Implement high-quality software and analysis code following best practices (version control, testing, documentation, reproducibility).

· Contribute to statistical and machine-learning workflows for biomarker extraction, classifier development, and performance analysis.

· Generate documentation, validation reports, and analysis artifacts aligned with design control, quality systems, and regulatory requirements (e.g., IVDR, FDA submissions, CLIA/LDT workflows).

· Execute analyses that support assay verification/validation, analytical performance studies, and clinical trial data deliveries.

· Perform in-depth analyses of NGS and methylation datasets, including feature extraction, QC, differential methylation analysis, classifier performance evaluation, and troubleshooting.

· Support internal reports, presentations, and cross-functional data reviews.

· Contribute to the scientific rationale and interpretation of results relevant to CRC early detection.

What you’ll bring:

Required qualifications

· PhD, MSc, or equivalent in Bioinformatics, Computational Biology, Genomics, or related field.

· 3–5+ years of industry experience (biotech, medtech, diagnostics), ideally in cancer early detection, liquid biopsy, or NGS-based diagnostics.

· Strong expertise in:

o NGS data processing for cfDNA or methylation-based assays

o Methylation analysis, feature calling, biomarker discovery

o Statistical modeling and/or machine learning applied to diagnostic development

· Demonstrated ability to work in a regulated or product-oriented environment, with familiarity in design controls, validation, documentation, and quality processes.

· Proficiency in Python, workflow development (Nextflow, Snakemake, WDL), and cloud-based computational environments.

· Strong communication skills and ability to collaborate with multidisciplinary teams.

· Ability to work in a fast-paced, delivery-focused environment with high operational rigor.

Preferred qualifications

· Experience supporting analytical validation, clinical studies, or regulatory submissions for molecular diagnostics (IVD, LDT, FDA, IVDR).

· Familiarity with large-scale data systems, cloud infrastructure (AWS/GCP/Azure), containerization (Docker), and CI/CD practices.

· Understanding of wet-lab processes and constraints in NGS assay development.

· Prior experience in translating research bioinformatics methods into reproducible, production-ready pipelines.

· Experience in CRC or other cancer early detection programs.